SUBSTITUTED PTERIDINONES, PYRIMIDINES, PYRROLOPYRIMIDINES, AND PURINES AS P90 RIBOSOMAL S6 PROTEIN KINASE-2 (RSK2) INHIBITORS: PHARMACOPHORE MODELING DATA

The RSK2 kinase is a downstream effector of the Ras/Raf/MEK/ERK pathway FIBRE CLINIX VOLUME BOOSTER that is aberrantly active in a range of cancer types and has been recognized an anticancer target.The inhibition of RSK2 kinase activity would disrupt multiple pro-cancer processes; however, there are few RSK2 inhibitors.The data have been obtained f

Behavioral addictions such as gambling, video games, sex, and shopping share many clinical features with substance use addictions including etiology, course, and neurobiology.Yet, the treatment of behavioral and substance use addictions tends to be separated.However, we argue that a more effective and efficient treatment approach is to conceptualiz

Sarcasm is a form of communication where the individual states the opposite of what is implied.Therefore, detecting a sarcastic tone is somewhat complicated due to its ambiguous nature.On the other hand, identification of sarcasm is vital to various natural language processing tasks such as sentiment analysis and text summarisation.However, researc

Type 2 diabetes mellitus (T2DM), characterized by insulin resistance and unclear pathogenesis, is a serious menace to human health.Bile acids are the end products of cholesterol catabolism and play an important role in maintaining cholesterol homeostasis.Furthermore, increasing studies suggest Pro Stitched Jersey that bile acids may regulate glucos